Although the anti-tumor effects of nonspecific active immunization with bacterial adjuvant products may be limited, diverse biological response modifiers(BRM) including BCG, Corynebacterium par.,um and Brucella .abortus have been employed to enhance the immune response through the activation of macrophages and natural killer cells and to restore the T cell function of cancer patients.
Propionibacterium acres serotype ff that is a predominant resident microorganism of the skin is most similar to previous descriptions of Corynebacterium parvuan. In our previous study on the quantitative bacteriology of P. acres isolated from the skin and serology with sera obtained from healthy persons, it was found that the distribution of serotype I was much higher than that of serotype I[ . However, the physiological role and significance of immunological function of two serotypes as BRVI´s were not elucidated.
In this study, nonspecific tumor immunity of the saline extracts of cell wall components and ether extracted bacilli of P. acres serotype I and R , and Brucella aboturs against the growth of Sarcoma 180 ascites tumor cells in ICR-JCR mice was assessed.
The saline extracts of cell wall components appeared to be more effective than the ether extracted bacilli to inhibit the growth of ascites tumor cells. Mean survival days of mice administered with either the saline extracts of cell wall components of P. acres serotype 1 or the ether extracted intact bacilli of P. .acnes,seroype ff were significantly extended in comparison with that of control group.
These ruseults indicated that the enhancement of nonspecific immune response by P. acres was associated with cell wall components, but there was no significant difference between two serotypes of P. acres in antitumor immunization aganist Sarcoma 180 ascites cells in mice.
|